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產(chǎn)品規(guī)格
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BN41186R-100ul
100ul
￥2360.00
交叉反應：Rat(predicted:Human,Mouse,Pig,Cow,Horse) 推薦應用：WB,ELISA
BN41186R-200ul
200ul
￥3490.00
交叉反應：Rat(predicted:Human,Mouse,Pig,Cow,Horse) 推薦應用：WB,ELISA
產(chǎn)品描述
| 英文名稱 | Aminoacylase 1 |
| 中文名稱 | 氨基?；?抗體 |
| 別 名 | ACY 1; ACY1; ACY1D; ACYLASE; EC 3.5.1.14; N acyl L amino acid amidohydrolase; ACY1_HUMAN. |
| 研究領(lǐng)域 | 免疫學 信號轉(zhuǎn)導 通道蛋白 新陳代謝 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應 | Rat, (predicted: Human, Mouse, Pig, Cow, Horse, ) |
| 產(chǎn)品應用 | WB=1:500-2000 ELISA=1:5000-10000 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 46kDa |
| 細胞定位 | 細胞漿 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human ACY1/Aminoacylase 1:201-300/408 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 產(chǎn)品介紹 | Aminoacylase 1 is a cytosolic, homodimeric, zinc binding enzyme that catalyzes the hydrolysis of acylated L amino acids to L amino acids and acyl group, and has been postulated to function in the catabolism and salvage of acylated amino acids. ACY1 has been assigned to chromosome 3p21.1, a region reduced to homozygosity in small cell lung cancer (SCLC), and its expression has been reported to be reduced or undetectable in SCLC cell lines and tumors. The amino acid sequence of human aminoacylase 1 is highly homologous to the porcine counterpart, and ACY1 is the first member of a new family of zinc binding enzymes. Function: Involved in the hydrolysis of N-acylated or N-acetylated amino acids (except L-aspartate). Subunit: Homodimer. Interacts with SPHK1. Subcellular Location: Cytoplasm. Tissue Specificity: Expression is highest in kidney, strong in brain and weaker in placenta and spleen. DISEASE: Defects in ACY1 are the cause of aminoacylase-1 deficiency (ACY1D) [MIM:609924]. ACY1D results in a metabolic disorder manifesting with encephalopathy, unspecific psychomotor delay, psychomotor delay with atrophy of the vermis and syringomyelia, marked muscular hypotonia or normal clinical features. Epileptic seizures are a frequent feature. All affected individuals exhibit markedly increased urinary excretion of several N-acetylated amino acids. Similarity: Belongs to the peptidase M20A family. SWISS: Q03154 Gene ID: 95 Database links: Entrez Gene: 95 Human Entrez Gene: 109652 Mouse Omim: 104620 Human SwissProt: Q03154 Human SwissProt: Q99JW2 Mouse Unigene: 334707 Human Unigene: 7165 Mouse Unigene: 3679 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
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